My research and book project, The Global Art-Fashion System, investigates cross-cultural art and fashion exchanges amidst globalization. With historical reflection, I explore modern and contemporary collaborations between Italian, Chinese, and US artists, designers, fashion companies, and cultural institutions. I posit these cases as part of a global art-fashion system considered vis-à-vis China’s New Silk Road initiative and within the deeply rooted context of Rome as cosmopolitan, cultural crossroads. My research reveals that prevalent but overlooked transnational art-fashion nexuses importantly figure into the New Silk Road, shedding light on how governments and private industries bolster the global art-fashion system. Simultaneously, my book showcases Italian, Chinese, and US artists and designers who resist unsustainable globalized conditions with creative projects that empathetically and ethically cross borders.